'Unite and conquer': enhanced prediction of protein subcellular localization by integrating multiple specialized tools

Table 4 Example proteins used for decision tracing

Sequence ID¹	Experimentally verified location	Predictions of mitochondrial location by individual LOC-tools^2,3									Predicted number of transmembrane domains^2,3
		TargetP	Subloc	pTARGET	SherLoc	Predotar	MitoProt	CELLO	PProwler	PASUB	Phobius	TMHMM	HMMTOP	SOSUI
YIL065C	Mitochondrial outer membrane	non	non	non	non	non	non	non	non	mit	1	1	1	1
YBR069C	Plasma membrane	non	non	non	non	non	non	non	non	mit	12	12	12	12
YLL022C	Nucleus	non	non	non	non	non	non	non	non	mit	0	0	0	0

¹ The sequences are retrieved from the yeast genome database [52]
² For references see text
³ "mit", predicted as mitochondrial protein; "non", predicted as non-mitochondrial protein

ISSN: 1471-2105