Table 3 Pattern response trends and selected over represented Gene Ontology categories.
Pattern | No. of genes | UV Response trends | IR Response trends | Selected over represented Gene Ontology categories* |
|---|---|---|---|---|
1 | 21 | Up regulated at 2 h post UV | Insignificant response | Transcription factor complex, development, nucleoplasm, regulation of transcription from Pol II promoter, morphogenesis |
2 | 57 | Up regulated at 2 h and 6 h post UV | Insignificant response | Nucleus, nucleic acid binding |
3 | 173 | Moderately up regulated at 2 h and peak 6 h post UV | Insignificant response | RNA metabolism, RNA processing, methyltransferase activity, nucleolus |
4 | 73 | Moderately down regulated at 2 h and up regulated at 6 h post UV | Insignificant response | Metabolism, nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism, regulation of transcription, DNA-dependent |
5 | 100 | Down regulated at 2 h post UV | Insignificant response | Regulation of transcription, transcription\DNA-dependent, nucleic acid binding, nucleus |
6 | 79 | Down regulated at 2 h and 6 h post UV | Insignificant response | Protein serine/threonine kinase activity, nucleus |
7 | 52 | Down regulated at 2 h and Moderately up regulated 6 h post UV | Insignificant response | Transcription regulator activity |
8 | 616 | Down regulated at 6 h post UV | Insignificant response | Purine nucleotide binding, protein modification, protein amino acid phosphorylation, ubiquitin cycle, kinase activity, cell growth and/or maintenance |
9 | 172 | Moderately up regulated at 2 h and peak 6 h post UV | Moderately up regulated at 2 h and down regulated at 24 h post IR | Nucleolus, ribosome biogenesis and assembly, mitotic cell cycle, rRNA processing, DNA replication, S phase of mitotic cell cycle |
10 | 23 | Moderately up regulated at 2 h and peak 6 h post UV | Up regulated at 2 h post IR, then decrease at 6 h and remained stable through 24 h post IR. | cell proliferation |
11 | 19 | Moderately up regulated at 2 h and peak 6 h post UV | Progressively up regulated from 2 h to 24 h post IR | Â |
12 | 47 | Down regulated at 2 h and Moderately down regulated 6 h post UV | Down regulated at 2 h post IR | protein binding |
13 | 385 | Moderately up regulated at 24 h post UV | Up regulated at 24 h post IR | Lysosome, lytic vacuole, complement activation |
14 | 563 | Moderately down regulated at 24 h post UV | Down regulated at 24 h post IR | Mitotic cell cycle, DNA replication and chromosome cycle, M phase, nuclear division, cell growth and/or maintenance, RNA processing, RNA metabolism, response to DNA damage stimulus, DNA repair, cell cycle checkpoint, cell growth and/or maintenance, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, |
15 | 49 | Insignificant response | Up regulated at 24 h post IR | cell adhesion |
16 | 115 | Down regulated at 6 h post UV | Up regulated at 24 h post IR | catalytic activity |
17 | 61 | Up regulated at 6 h post UV | Moderately down regulated at 2 h post IR | DNA binding |
18 | 56 | Down regulated at 6 h and 24 h post UV | Moderately up regulated at 24 h post IR | plasma membrane, morphogenesis |