An example of uniparental disomy in chromosome 13 in a bladder tumour sample. In this chromosome, we can distinguish uniparental disomy coloured in purple in a region of approximatively 20 Mb and an unbalance amplification in the rest of the q-arm coloured in orange and red. A. For each SNP heterozygous in the germline DNA, the normalized intensities (as defined in Methods equation 4) of each allele are plotted. The colours represent the estimated state of the SNP: black for state 0, blue for state 1, green for state 2, purple for state 3, orange for state 4 and red for state 5. B. Shown is the region of LOH. C. For each SNP homozygous in the germline DNA, the normalized intensities (as defined in Methods equation 4) of each allele are plotted. The absent allele is coloured in grey. D. Shown is the estimated sequence of hidden states. The colour indicates the posterior probabilities of the states: blue > 0.99, green > 0.95, orange > 0.9 and red < 0.9.