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Figure 1 | BMC Bioinformatics

Figure 1

From: Identification of tissue-specific cis-regulatory modules based on interactions between transcription factors

Figure 1

Schematic of module detection method based on TF interactions. Based on gene expression profiles across different tissues, we identified groups of genes that are preferentially expressed in tissues (e.g. gene C and D in the schematic). For each group of genes, we searched the binding sites of known TFs in promoter regions and determined the TF pairs whose binding sites tend to co-occur in close proximity. A tissue-specific TF interaction network was obtained from the analysis. We then scanned the genomic regions and identified cis-regulatory regions (CRMs). The CRMs are defined as regions enriched with TF interactions. Note the first steps were implemented in our previous work [22] while this paper focuses on the last step.

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