Figure 4

Dependence of regulatory activity on positions relative to gene structure. We calculated the probability for each position containing a CRM. The reference positions (origins in the x-axis) are transcription start sites, the respective start sites of introns and transcription end sites in three regions, respectively. The pink curve in the left panel is from random sequences which were generated with the same nucleic acids compositions and 1^st order transition probabilities, respectively, as those of the all promoter sequences in the human genome.