Predicting combinatorial binding of transcription factors to regulatory elements in the human genome by association rule mining

Table 1 High-confidence TF pairs verified in the literature.

TF pair	Gene Regulated	Source
Ap-2, p300	Mouse CITED4	[83]
Sp1, Gata2	Human PDGFβ receptor	[84]
Sp1, p300	Human ERK1	[126]
Ap-2, Egr1	Human tumor necrosis factor α, rat chromogranin B, human PNMT	[41–43, 67]
Ap-2, NFκB	Human tumor necrosis factor α	[41]
Egr1, Elk1	Human tumor necrosis factor α	[41, 132]
Egr1, Nf1	Human tissue factor pathway inhibitor 2	[40]
Egr1, p300	Human tumor necrosis factor α	[67]
Egr1, Sp1	Human TFPI-2, human SOD, human cd95, human TNFα	[40, 74, 97, 132]
Sp1, p53	Human Icam1	[44, 45]
Mzf1, Sp1	Human N-cadherin	[115]
Sp1, Srebp	Porcine LDL receptor, rat FAS	[123, 128]
Usf, Sp1	Rat FAS, human Top3, human liver fructose1,6 biphosphatase	[101, 119, 123]
Aml1, NFκB	Human GM-CSF	[66]
Aml1, Srebp	Human fatty acid synthase	[64]
Elk1, p300	Human tumor necrosis factor α	[132]
Gata2, NFκB	Human erythropoietin	[112]
Gata2, Sp1	Human PDGF receptor	[84]
Nf1, NFκB	Human tissue factor pathway inhibitor 2	[40]
NFκB, p300	Human I-gamma 1, mouse tapasin	[87, 111]
Pax5, p300	Human immunoglobin κ	[133]
Ap-1, NFκB	Human interleukin 6, human RANTES, human TNFα, human GM-CSF	[41, 60, 70, 77]

Examples of high-confidence TF pairs that could be verified in the literature as co-regulators of mammalian genes.

ISSN: 1471-2105