PedGenie: meta genetic association testing in mixed family and case-control designs

BMC Bioinformatics

Table 5 Mixed design meta analysis of case-control and family-based/mixed-resource studies, ¹ null scenario. ²

Description	CMH Chi Square	CMH Chi-Square Trend	Meta Odds Ratio
			Aa vs. AA	aa vs. AA
Statistic, PedGenie 2.1	0.23	0.22	0.97	0.94
Empirical p-value, mean (SD)	0.886 (0.010)	0.616 (0.016)	0.630 (0.029)	0.786 (0.030)
Empirical 95% CI: lower (SD)			0.85 (0.005)	0.60 (0.013)
Empirical 95% CI: upper (SD)			1.10 (0.006)	1.48 (0.032)
Statistic, SAS^®	0.23	0.22	0.97	0.94

¹Studies 2.1, 2.2, and 2.3.
²1,000 configurations in the PedGenie null.
³P-values and 95% CIs are not given as SAS cannot account for dependent relationships, and hence are not appropriate.

ISSN: 1471-2105