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Table 6 Mixed design meta analysis of case-control and family-based/mixed-resource studies, 1 alternate scenario. 2

From: PedGenie: meta genetic association testing in mixed family and case-control designs

Description

CMH Chi Square

CMH Chi-Square Trend

Meta Odds Ratio

   

Aa vs. AA

aa vs. AA

Statistic, PedGenie 2.1

28.22

27.22

1.31

2.03

Empirical p-value, mean (SD)

<0.0001 (<0.0001)

<0.0001 (<0.0001)

<0.0001 (<0.0001)

0.0001 (0.0001)

Empirical 95% CI: lower (SD)

  

1.16 (0.0020)

1.42 (0.0069)

Empirical 95% CI: upper (SD)

  

1.49 (0.0026)

2.92 (0.0143)

Statistic, SAS®

28.22

27.22

1.31

2.03

  1. 1Studies 2.1, 2.2, and 2.3.
  2. 210,000 configurations in the PedGenie null.
  3. 3P-values and 95% CIs are not given as SAS cannot account for dependent relationships, and hence are not appropriate.