Figure 5

PIVET Results Between Apoenzyme and ATP Bound CDK2 Conformer. Residue pair changes between apo and ATP bound conformers of CDK2 and their effect on global fluctuation. 27 residue pairs were observed to have a change in neighboring. Shown are: gain of a neighbor (red), loss of a neighbor (blue), loss of 2 neighbors (green), and no net change observed (orange). The table lists the impact of residue pairs as a percent of overall structure and direction of change where -1 indicate loss of a neighbor (disruption) and 1 a gain of a neighbor in going from the apo to the ATP bound conformer.