| |
TOP 10 PIVET
|
BOTTOM 10 PIVET
|
|---|
| |
Residue Pairs
|
Impact
|
Δ
|
Residue Pairs
|
Impact
|
Δ
|
|
Activation Stage 2 (1 HCK to 1 FIN)
|
A 114
|
A 142
|
23.47%
|
1
|
A 231
|
A 238
|
3.06%
|
1
|
| |
A 156
|
A 163
|
22.11%
|
-1
|
A 294
|
A 103
|
3.06%
|
1
|
| |
A 149
|
A 146
|
15.65%
|
1
|
A 15
|
A 36
|
2.38%
|
-1
|
| |
A 56
|
A 67
|
15.31%
|
-1
|
A 90
|
A 296
|
2.38%
|
1
|
| |
A 151
|
A 122
|
14.63%
|
1
|
A 163
|
A 160
|
2.38%
|
1
|
| |
A 123
|
A 149
|
14.63%
|
1
|
A 162
|
A 157
|
2.04%
|
-1
|
| |
A 122
|
A 152
|
14.29%
|
1
|
A 295
|
A 137
|
1.70%
|
1
|
| |
A 124
|
A 149
|
14.29%
|
1
|
A 157
|
A 160
|
1.36%
|
-1
|
| |
A 151
|
A 123
|
13.95%
|
1
|
A 36
|
A 16
|
1.36%
|
-1
|
| |
A 177
|
A 158
|
13.95%
|
1
|
A 44
|
A 41
|
1.02%
|
-1
|
|
Activation Stage 3 (1 FIN to 1 JST)
|
A 278
|
A 113
|
20.81%
|
1
|
A 241
|
A 221
|
2.35%
|
1
|
| |
A 222
|
A 216
|
20.47%
|
1
|
B 284
|
B 287
|
2.35%
|
-1
|
| |
A 110
|
A 142
|
20.47%
|
1
|
B 284
|
B 281
|
2.01%
|
-1
|
| |
B 310
|
B 230
|
19.46%
|
1
|
B 372
|
B 370
|
2.01%
|
1
|
| |
B 292
|
A 40
|
17.11%
|
-1
|
B 266
|
B 271
|
2.01%
|
-1
|
| |
B 302
|
B 241
|
17.11%
|
1
|
A 180
|
A 158
|
1.68%
|
-1
|
| |
A 158
|
A 177
|
16.78%
|
-1
|
A 245
|
A 221
|
1.68%
|
1
|
| |
A 74
|
A 38
|
16.78%
|
-1
|
B 389
|
B 386
|
1.68%
|
-1
|
| |
B 350
|
B 390
|
16.78%
|
1
|
B 279
|
B 284
|
1.68%
|
-1
|
| |
A 180
|
A 177
|
16.44%
|
1
|
B 362
|
B 395
|
1.01%
|
-1
|
|
Activation Stage 4 (1 JST to 1 QMZ)
|
B 181
|
A 121
|
17.11%
|
-1
|
A 223
|
A 228
|
1.68%
|
-1
|
| |
B 193
|
B 241
|
16.11%
|
-1
|
B 279
|
B 284
|
1.68%
|
1
|
| |
A 37
|
A 45
|
15.44%
|
-1
|
A 253
|
A 248
|
1.01%
|
1
|
| |
A 279
|
A 283
|
15.10%
|
1
|
B 198
|
B 202
|
1.01%
|
-1
|
| |
B 292
|
A 39
|
14.77%
|
-1
|
B 279
|
B 291
|
1.01%
|
-1
|
| |
B 308
|
B 305
|
14.77%
|
-1
|
B 334
|
B 359
|
0.67%
|
-1
|
| |
B 340
|
B 394
|
14.77%
|
-1
|
B 284
|
B 287
|
0.67%
|
1
|
| |
A 113
|
A 278
|
14.43%
|
-1
|
B 347
|
B 341
|
0.67%
|
1
|
| |
B 289
|
A 40
|
14.43%
|
-1
|
B 419
|
B 414
|
0.34%
|
-1
|
| |
A 42
|
A 38
|
14.09%
|
-1
|
B 391
|
B 362
|
0.34%
|
-1
|
- The 10 residue pairs with the most and least impact on global fluctuation for each activation stage as determined by PIVET. The impact and direction of change for each residue pair with corresponding chains (A and B) are indicated by a loss (-1) and gain (1) of neighbors. Residues are ranked according to their impact on fluctuations in CDK2 only.
