Table 1 Top 10 Most and Least Impacting Residue Pairs on Global Fluctuation for CDK2
| Â | TOP 10 PIVET | BOTTOM 10 PIVET | ||||||
|---|---|---|---|---|---|---|---|---|
|  | Residue Pairs | Impact | Δ | Residue Pairs | Impact | Δ | ||
Activation Stage 2 (1 HCK to 1 FIN) | A 114 | A 142 | 23.47% | 1 | A 231 | A 238 | 3.06% | 1 |
| Â | A 156 | A 163 | 22.11% | -1 | A 294 | A 103 | 3.06% | 1 |
| Â | A 149 | A 146 | 15.65% | 1 | A 15 | A 36 | 2.38% | -1 |
| Â | A 56 | A 67 | 15.31% | -1 | A 90 | A 296 | 2.38% | 1 |
| Â | A 151 | A 122 | 14.63% | 1 | A 163 | A 160 | 2.38% | 1 |
| Â | A 123 | A 149 | 14.63% | 1 | A 162 | A 157 | 2.04% | -1 |
| Â | A 122 | A 152 | 14.29% | 1 | A 295 | A 137 | 1.70% | 1 |
| Â | A 124 | A 149 | 14.29% | 1 | A 157 | A 160 | 1.36% | -1 |
| Â | A 151 | A 123 | 13.95% | 1 | A 36 | A 16 | 1.36% | -1 |
| Â | A 177 | A 158 | 13.95% | 1 | A 44 | A 41 | 1.02% | -1 |
Activation Stage 3 (1 FIN to 1 JST) | A 278 | A 113 | 20.81% | 1 | A 241 | A 221 | 2.35% | 1 |
| Â | A 222 | A 216 | 20.47% | 1 | B 284 | B 287 | 2.35% | -1 |
| Â | A 110 | A 142 | 20.47% | 1 | B 284 | B 281 | 2.01% | -1 |
| Â | B 310 | B 230 | 19.46% | 1 | B 372 | B 370 | 2.01% | 1 |
| Â | B 292 | A 40 | 17.11% | -1 | B 266 | B 271 | 2.01% | -1 |
| Â | B 302 | B 241 | 17.11% | 1 | A 180 | A 158 | 1.68% | -1 |
| Â | A 158 | A 177 | 16.78% | -1 | A 245 | A 221 | 1.68% | 1 |
| Â | A 74 | A 38 | 16.78% | -1 | B 389 | B 386 | 1.68% | -1 |
| Â | B 350 | B 390 | 16.78% | 1 | B 279 | B 284 | 1.68% | -1 |
| Â | A 180 | A 177 | 16.44% | 1 | B 362 | B 395 | 1.01% | -1 |
Activation Stage 4 (1 JST to 1 QMZ) | B 181 | A 121 | 17.11% | -1 | A 223 | A 228 | 1.68% | -1 |
| Â | B 193 | B 241 | 16.11% | -1 | B 279 | B 284 | 1.68% | 1 |
| Â | A 37 | A 45 | 15.44% | -1 | A 253 | A 248 | 1.01% | 1 |
| Â | A 279 | A 283 | 15.10% | 1 | B 198 | B 202 | 1.01% | -1 |
| Â | B 292 | A 39 | 14.77% | -1 | B 279 | B 291 | 1.01% | -1 |
| Â | B 308 | B 305 | 14.77% | -1 | B 334 | B 359 | 0.67% | -1 |
| Â | B 340 | B 394 | 14.77% | -1 | B 284 | B 287 | 0.67% | 1 |
| Â | A 113 | A 278 | 14.43% | -1 | B 347 | B 341 | 0.67% | 1 |
| Â | B 289 | A 40 | 14.43% | -1 | B 419 | B 414 | 0.34% | -1 |
| Â | A 42 | A 38 | 14.09% | -1 | B 391 | B 362 | 0.34% | -1 |