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Figure 1 | BMC Bioinformatics

Figure 1

From: Inferring activity changes of transcription factors by binding association with sorted expression profiles

Figure 1

The schematic representation of our method. (a) The inputs are the gene expression data and the binding affinity data such as ChIP-chip data, motif discovery data or PWMs scanning data. (b) The possible patterns of binding affinities of ranked genes in a decreasing order of their expression changes. The top red and bottom blue plot represent cases where the up-regulated (red) or down-regulated (blue) genes tend to have high binding affinity by a TF. The middle plot (black) shows when there is no significant correlation between the gene expression data and the binding affinity data. (c) The presentation of the binding affinity patterns using cumulative distribution functions. The binding affinity patterns shown in (b) is regarded as probability density functions. The lower table shows the relationship between TF activity change and the expression change of the target genes.

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