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Table 2 Representation of an experimentally derived I-Ag7 motif

From: Predicting peptides binding to MHC class II molecules using multi-objective evolutionary algorithms

Position

Well-Tolerated

Weakly-Tolerated

Non-Tolerated

P1

VEQMHLPD

-

R

P2

-

-

-

P3

-

-

-

P4

ILPV

HY

QEK

P5

-

-

-

P6

ATSNV

-

LYQK

P7

QVYLHINRF

-

-

P8

-

-

-

P9

ED

SM

LYTQK

  1. The description of experimentally determined I-Ag7 9-mer peptide binding motif by Reizis: each position accommodates a well-tolerated, weakly-tolerated, or non-tolerated amino acid. The positions P4, P6 and P9 are the primary anchor positions where binding is highly likely to occur.
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BMC Bioinformatics

ISSN: 1471-2105

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