Figure 1

Identification of steady states using SQUAD. Graphical description of the identification of steady states using SQUAD. The model for the T-helper cell network (upper left figure) is loaded into SQUAD (upper center figure) using a CellDesigner sbml file. SQUAD displays the steady states identified in the network (upper right figures) through a scrollable list containing the values of the active nodes for each configuration. In addition the steady states can be visualized directly on the network topology (lower figures). For the T-helper network three steady states exist. Based on the molecular fingerprint, each state can be mapped to an existing biological state: State1 with all the nodes inactive corresponds to the Th0 cells. State2 with active IFNγ corresponds to the Th1 cells. State3 with active IL-4 corresponds to the Th2 state.