Figure 4

Structural analysis of GUC3, one of the two outliers in Figure 3. Unfavorable interactions involving the two binding arms and the end sequences of the ribozyme catalytic core are present in structures predicted for GUC3. (A) The representative structure (i.e., the centroid of a structural cluster [35]) for 44.9% of structures predicted by Sfold for the ribozyme sequence. (B) The representative structure for 29.8% of the predicted structures. (C) The representative structure for 20.9% of the predicted structures. (D) The representative structure for the remaining 4.4% of the predicted structures. The sequence for the ribozyme 5' binding arm ends at A⁹, and the sequence for the ribozyme 3' binding arm starts at A³².