Table 1 The significant transcription factors in order by detected frequencies via our method under different environmental stresses in S. cerevisiae.

Hyper-osmotic Shock

Skn7*

Smp1*

Fkh2

Fkh1

Hsf1*

Mbp1*

Phd1*

Gcn4

Yap6*

Mth1*

Abf1*

Fhl1*

Cin5*

Rap1*

Reb1*

Hypo-osmotic Shock

Swi6

Ino4

Phd1*

Swi5

Bas1*

Skn7*

Mth1*

Fkh2

Ixr1

Hap4

Abf1*

Fhl1*

Cin5*

Rap1*

Reb1*

Heat Shock from 25°C to 37°C

Swi4

Hsf1*

Phd1*

Gcn4*

Sum1*

Pho4

Skn7*

Fkh2

Fkh1

Swi6

Abf1*

Fhl1*

Cin5*

Rap1*

Reb1*

Temperature Shift from 37°C to 25°C

Hsf1*

Mcm1*

Gat3

Stb1

Mbp1*

Gcn4*

Hap4

Cbf1

Ndd1*

Skn7*

Abf1*

Fhl1*

Cin5

Rap1*

Reb1*

Mild Heat Shock at Variable Osmolarity

Hsf1*

Skn7*

Swi6

Ino4

Mbp1*

Hap4

Swi5

Fkh1

Dot6

Swi4

Abf1*

Fhl1*

Cin5*

Rap1*

Reb1*

Hydrogen Peroxide Treatment

Mcm1

Gcn4

Skn7*

Hsf1*

Fkh1

Hap4

Cbf1

Sum1

Swi6

Mbp1

Abf1*

Fhl1*

Cin5*

Rap1*

Reb1

Cell cycle

Mcm1*

Swi4*

Phd1

Mbp1*

Swi5*

Fkh2*

Fkh1*

Yap5

Stb1

Skn7*

Abf1*

Fhl1*

Cin5*

Rap1*

Reb1*