Figure 4
From: Ab initio identification of human microRNAs based on structure motifs
Free energy distributions of sequence windows (central 70 nt folding). Frequency distribution (in percent) of 173 predicted miRNAs on chromosome 19 matches the distribution of all 474 known human miRNAs (miRBase 9.0). The normal distribution of all tested 88,808 structures is significantly shifted towards higher free energies with mean around -15 kcal/mol, compared to about -30 for miRNAs. Structures with lower free energy, especially below -30, are more likely miRNAs. Energies are rounded to integers.