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Figure 3 | BMC Bioinformatics

Figure 3

From: Identifying protein complexes directly from high-throughput TAP data with Markov random fields

Figure 3

Comparison of sensitivity and specificity for all clustering solutions on Gavin06. Only proteins with annotation from MIPS (a) and Reguly (b) are considered. The curve for MRF is generated as we filter out clusters with high observed errors. The curve for MCL is generated for different inflation parameters, [1.2, 0.2, 5.0], which are recommended by the MCL program. Highly specific solutions are the MCODE and the Gavin06 (core) solutions with show low sensitivity due to many proteins left unassigned. MRF maintains better sensitivity while losing only a few percent in specificity. In this respect, MRF performs better than MCL because it maintains high specificity without losing sensitivity.

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