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Table 1 List and ranking of the predicted aggregation-prone regions in the different disease-linked polypeptides analyzed in this study and comparison with the available experimental data.

From: AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

Protein Experimental regiona Predicted regionb Rankingc References
Abri 1–34 4–9 2/2 [52]
   15–28 1/2  
Adan 1–34 4–9 2/2 [53]
   15–24 1/2  
  68–78 66–77 1/6 [54–56]
α-Synuclein 31–109 36–42 2/6 [56]
   49–55 4/6  
   87–94 5/6  
Amphoterin 12–27 14–22 2/3 [57]
Amyloid-β-protein 17–21 17–22 2/2 [58]
  31–36/38–42 30–42 1/2  
Apoliprotein A-I 1–83 13–21 2/2 [59]
Apoliprotein A-II N-terminal fragments 1–19 1/3 [11]
Apoliprotein A-IV N-terminal fragments 1–19 1/6 [11]
Apoliprotein C-II 57–74 60–67 2/3 [60]
   69–76 1/3  
β2-Microgobulin 21–41 22–30 2/2 [61]
  59–79 59–70 1/2 [62]
Exon 30 Tropoelastin 1–25 1–7 2/2 [63]
   9/18 1/2  
Fibrinogen A α-chain 501–506 499–521 1/6 [64]
  482–504 501–506 1/5  
Glycophorin A 70–98 74–98 1/4 [65]
Insulin 1–38 12–19 1/3 [66]
   21–27 3/3  
Islet amyloid polypeptide 8–20 13–18 1/2 [67]
  20–29 24–28 2/2 [68]
Lysozyme (Hen) 40–64 54–62 2/4 [69]
  49–101 76–84 3/4 [70]
Medin 47–54 49–55 1/3 [71]
Myoglobin (Horse) 101–118 101–115 1/4 [72]
Prion Protein 106–147 117–136 3/6 [73]
   138–142 6/6  
Prolactin 1–34 10–32 2/9 [74]
Pulmonary surfactant protein 24–58 31–59 1/5 [25]
Serum Amyloid A 2–12 1–9 1/2 [75]
Tau 301–320 304–311 1/2 [27]
  10–20 12–19 2/7 [76]
Transthyretin 105–115 105–112 3/7 [77]
   114–123 4/7  
  1. aSequence stretches experimentally identified as critical for protein aggregation.
  2. bCoincident aggregation-prone segments as predicted by AGGRESCAN.
  3. cThe rank position refers to the entire protein and reflects the importance of this specific "hot spot" (HS) relative to all the aggregation-prone regions identified by AGGRESCAN in the protein. (i.e., 1/4 indicates that this HS has the highest aggregation propensity of the four detected in a particular sequence by the software)