Table 2 Comparison of AGGRESCAN predictions with the structural composition of different amyloid fibrils.
From: AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides
Protein | Structure (β-strands) | Prediction | Reference |
|---|---|---|---|
Aβ1-40 | β 1: 12–24 | 17–22 | [78] |
|  | β 2: 30–40 | 30–40 |  |
Amylin | β 1: 12–17 | 13–18 | [79] |
|  | β 2: 22–27 | 24–28 |  |
|  | β 3: 31–37 | - | [80] |
HET's Prion | β 1: 226–234 | - |  |
|  | β 2: 237–245 | 238–248 |  |
|  | β 3: 262–270 | 263–267 |  |
|  | β 4: 273–282 | 272–276 |  |
Mouse Prion (89–143) | β 1: 112–124 | 115–129 | [81] |
β2- microglobulin (20–41) | β 1: 21–30 | 22–30 | [82] |
|  | β 2: 33–40 | - |  |
Transthyretin (105–115) | β 1: 105–115 | 105–112 | [83] |