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Table 4 Comparison of the predicted and experimentally tested effects of mutations on the aggregation propensity of amyloidogenic proteins.

From: AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

Sequence Name ΔNa4vSSa Experimentalb References
Peptide Aβ42 A21G -16 - [84]
Peptide Aβ42 E22K 15 + [84]
Peptide Aβ42 E22G 29 + [84]
Peptide Aβ42 E22Q 5 + [84]
Peptide Aβ42 F19P -68 - [85]
Peptide Aβ42 F19T -63 - [35]
Peptide Aβ42 D23N 16 + [86]
Peptide Aβ42 F19D -118 - [12]
Peptide Aβ42 I31L -15 - [87]
Peptide Aβ42 I32L -15 - [87]
Peptide Aβ42 I41G -62 - [87]
Peptide Aβ42 I41A -49 - [87]
Peptide Aβ42 I41L -12 - [87]
Peptide Aβ42 A42G -10 - [87]
Peptide Aβ42 A42V 32 + [87]
Peptide Aβ42 Δ 1–4 59 + [88]
Peptide Aβ42 Δ 1–9 237 + [88]
Peptide Aβ42 Δ 40–42 -63 - [88]
Peptide AβgΔ 41–42 -34 - [36]
Peptide Aβg5 89 + [36]
Peptide Aβg6 111 + [36]
Peptide Aβg7 167 + [36]
Peptide Aβ42 V12E+V18E+M35T+I41N -312 - [87]
Peptide Aβ42 F19S+L34P -123 - [87]
TAU R5L 2 + [89]
TAU R406W 2 + [90]
TAU G272V 2 + [90]
TAU Y310W 0 = [39]
TAU P301L 1 + [40]
TAU S320F 2 + [91]
α-synucleinA30P -1 = [92]
α-synucleinE46K 2 + [92]
α-synucleinA53T -1 + [92]
α-synucleinA76E -5 - [93]
α-synucleinA76R -3 - [93]
Amylin (Rat) R18H 9 + [94]
Amylin (Rat) L23F 17 + [94]
Amylin (Rat) V26I 11 + [94]
Amylin (Rat) R18H+L23F+V26I 34 + [94]
Amylin (human) (22–27) N22A 21 + [68]
Amylin (human) (22–27) F23A -59 - [68]
Amylin (human) (22–27)G24A 16 + [68]
Amylin (human) (22–27) I26A -61 - [68]
Amylin (human) (22–27) L27A -23 - [68]
Amylin (human) S20G -106 + [95]
Amylin (human) ProIAPP -90 +? [96]
Human PrP H111A 5 +/= [97]
Human PrP H111K 0 -/= [97]
Human PrP A117V 7 + [97]
Human PrP V210I 1 + [98]
Stefin R68X 37 + [41]
Stefin G4R -6 - [41]
SH3 n47a 17 + [46]
  1. aRelative change in Na4vSS upon mutation, expressed as percentage.
  2. ΔNa 4 vSS = ((Na 4 vSS mut - Na 4 vSS wt )/|Na 4 vSS wt |)*100
  3. Na4vSS mut refers to the Na4vSS value of the mutant sequence.
  4. Na4vSS wt refers to the Na4vSS value of the wild type sequence.
  5. bChanges in aggregation determined experimentally.
  6. Symbols: + increase; - decrease; = no significant change.