AGGRESCAN: a server for the prediction and evaluation of

BMC Bioinformatics

Table 5 Comparison of the different AGGRESCAN parameters for globular, natively unstructured, amyloidogenic, soluble and insoluble proteins.

Set Name	Globular¹	Unfolded²	Amyloid³	IBs⁴	Soluble⁵
*a3vSA*	*-0.04*	*-0.28*	*-0.12*	*-0.02*	*-0.05*
nHS	9.54	5.63	5.86	11.97	10.34
*NnHS*	*3.89*	*2.06*	*2.89*	*3.50*	*3.35*
AAT	29.94	18.21	24.51	41.27	34.43
THSA	25.58	14.97	21.26	36.00	29.61
TA	-5.17	-60.95	-26.42	-5.00	-5.55
*AATr*	*0.12*	*0.07*	*0.13*	*0.13*	*0.12*
*THSAr*	*0.11*	*0.05*	*0.11*	*0.11*	*0.09*
*Na4vSS*	*-4.26*	*-28.73*	*-12.96*	*-2.51*	*-5.18*

In bold and italics are shown those parameters that are normalized by the number of residues, allowing direct comparison of datasets independently of protein size.
¹Natively globular proteins: 160 proteins randomly selected from SCOP (the ASTRAL40 set)
²Natively intrinsically unstructured proteins: 51 proteins
³Amyloidogenic proteins: 57 proteins
⁴Proteins forming inclusion bodies when overexpressed in bacteria: 121 proteins
⁵Proteins which are soluble when overexpressed in bacteria: 38 proteins

ISSN: 1471-2105