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Table 5 Comparison of the different AGGRESCAN parameters for globular, natively unstructured, amyloidogenic, soluble and insoluble proteins.

From: AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

Set Name Globular1 Unfolded2 Amyloid3 IBs4 Soluble5
a3vSA -0.04 -0.28 -0.12 -0.02 -0.05
nHS 9.54 5.63 5.86 11.97 10.34
NnHS 3.89 2.06 2.89 3.50 3.35
AAT 29.94 18.21 24.51 41.27 34.43
THSA 25.58 14.97 21.26 36.00 29.61
TA -5.17 -60.95 -26.42 -5.00 -5.55
AATr 0.12 0.07 0.13 0.13 0.12
THSAr 0.11 0.05 0.11 0.11 0.09
Na4vSS -4.26 -28.73 -12.96 -2.51 -5.18
  1. In bold and italics are shown those parameters that are normalized by the number of residues, allowing direct comparison of datasets independently of protein size.
  2. 1Natively globular proteins: 160 proteins randomly selected from SCOP (the ASTRAL40 set)
  3. 2Natively intrinsically unstructured proteins: 51 proteins
  4. 3Amyloidogenic proteins: 57 proteins
  5. 4Proteins forming inclusion bodies when overexpressed in bacteria: 121 proteins
  6. 5Proteins which are soluble when overexpressed in bacteria: 38 proteins