False occurrences of functional motifs in protein sequences highlight evolutionary constraints

BMC Bioinformatics

Table 2 The information content (IC)

Pattern region		N	IC average	Q₂₅	Q₇₅
I	sprot100	63 (5%)	26.8 ± 0.7	23.3	30.7
III		36 (3%)	20.3 ± 0.5	18.9	21.9
II		1196 (92%)	33.3 ± 0.3	26.4	37.4
II*		333	24.2 ± 0.2	22.3	26.3
μ = FP = 0		863	36.9 ± 0.4	30.2	40.5
I	human100	20	24.5 ± 1.2	20.6	28.7
III		2	17.3 ± 0.5	17.1	17.5
II		830	32.8 ± 0.4	25.2	37.4
II*		150	21.9 ± 0.2	20.3	23.6
μ = FP = 0		680	35.2 ± 0.4	28.3	39.0
I	yeast100	10	24.4 ± 2.1	21.4	29.2
III		0	-	-	-
II		598	31.9 ± 0.4	25.4	35.6
II*		65	20.8 ± 0.3	19.5	21.8
μ = FP = 0		532	33.2 ± 0.4	26.9	36.5

Region II* is the region II without patterns for which λ = FP = 0; Q₂₅ is the 25^th percentile and Q₇₅ is the 75^th percentile; N is the number of patterns in the corresponding region.

ISSN: 1471-2105