Figure 2
From: Inference of miRNA targets using evolutionary conservation and pathway analysis
Examples of inferred phylogenetic distributions of functional target sites. Comparison of the inferred phylogenetic distribution of functional target sites across vertebrate species (human – H. sapiens, chimp – P. troglodytes, rhesus maccaque – M. mulatta, mouse – M. musculus, rat – R. norvegicus, cow – B. taurus, dog – C. familiaris, opossum – M. domestica, chicken – G. gallus) for 4 different miRNAs. Starting from human at the root the thickness of the branches of the tree represents the fraction of putative target sites inferred to be selected along that branch of the tree. The bars at each internal node indicate what fraction of sites remains under selection in both descending branches (green), only the left descending branch (red), and only the right descending branch (blue). For each of the human miRNAs shown in this figure, there exists at least a miRNA with the same 1–8 "seed" sequence in all vertebrates in the tree.