Figure 2

Metabolite profiles for the three-way comparison. Mouse liver extract metabolite profiles acquired by CE-TOFMS two hours after intraperitoneal injection with (a) vehicle (Control), (b) diethylmaleate (DEM), a non-protein thiol-depleting chemical, or (c) buthionine sulfoximine (BSO), an inhibitor of γ-glutamylcysteine synthase. The plotted datasets are averages of five normalized replicate datasets for cation measurements originating from our previous work [2]. The averaged datasets are visualized as density plots. For all plots, numbered ovals (annotation labels) indicate the expected locations of peaks of a set of known chemical compounds and are used for identification of metabolites on the density plots [2,3].