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Table 1 Similarities Between all SPOUT Structures Detectable With DALI

From: Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases

PDB id

name

organism

specificity

family

1v2x

1zjr

2ha8

1gz0

1ipa

1x7o

1j85

1nxz

1vhk

1v6z

1z85

1k3r

1ns5

1to0

1vh0

1o6d

1oy5

1p9p

1uaj

1v2x

TrmH

T. thermophilus

tRNA:Gm18

COG0566A

X

21.4

21

22.5

21.7

20.8

16.2

11.8

12.9

17.7

10.3

13.2

9.1

8.8

8.7

8.2

7.2

8.3

7.4

1zjr

TrmH

A. aeolicus

tRNA:Gm18

COG0566A

21.4

X

19.3

22.3

17.7

17.6

14.5

10.7

11

12.2

9.1

11.1

7.8

7.9

7.4

7.4

5.5

6.4

6.3

2ha8

HTRBP1

H. sapiens

tRNA:Gm18?

COG0566A

21

19.3

X

20.3

19.2

20.5

17.7

12.4

12.9

13

10.2

10.9

8.6

9

8.5

9.1

7.8

8.9

8.9

1gz0

RlmB

E. coli

23S rRNA:Gm2251

COG0566B

22.5

22.3

20.3

X

23.6

22.3

17.3

12.3

11.5

13.8

11.2

13.3

8.3

8.2

7.9

7.9

6.6

7.2

6.7

1ipa

RrmA

T. thermophilus

unknown

COG0566C

21.7

17.7

19.2

23.6

X

20.5

17.7

12.7

12.1

13.1

11.1

13.4

9.5

9.2

9

8

6.4

7.3

5.9

1x7o

AviRb

S. viridochromogenes

23S rRNA:Um2479

COG0566C

20.8

17.6

20.5

22.3

20.5

X

17.9

11.7

12.4

13.4

10.2

12.1

8.2

8.4

7.8

7.8

6.5

7.9

7.8

1j85

YibK

H. influenzae

unknown

COG0219

16.2

14.5

17.7

17.3

17.7

17.9

X

10.8

12.3

13

10.3

11.7

7.1

7.9

7.1

8.5

5.9

6.8

6.9

1nxz

RsmE

H. influenzae

16S rRNA:m3U1498?

COG1385

11.8

10.7

12.4

12.3

12.7

11.7

10.8

X

22.8

21

19.4

13.9

9.3

8.3

8.5

9.7

6.2

7.3

7.1

1vhk

YqeU

B. subtilis

16S rRNA:m3U1498?

COG1385

12.9

11

12.9

11.5

12.1

12.4

12.3

22.8

X

23

17.5

12.8

9

8.9

8.1

8.7

6.4

7.7

7.4

1v6z

TT1573

T. thermophilus

16S rRNA:m3U1498?

COG1385

13.8

12.2

13

13.8

13.1

13.4

13

21

23

X

14.3

13.8

8.3

8.4

7.3

7.7

5.8

7

6.8

1z85

TM1380

T. maritima

16S rRNA:m3U1498?

COG1385

10.3

9.1

10.2

11.2

11.1

10.2

10.3

19.4

17.5

14.3

X

11.2

5.2

5.9

5

5.9

5.9

5.9

4.9

1k3r

MT1

M. thermoautotrophicum

unknown

COG2106

13.2

11.1

10.9

13.3

13.4

12.1

11.5

13.9

12.8

13.8

11.2

X

10.6

10.2

8.5

9.7

7.4

7.9

7.7

1ns5

YbeA

E. coli

unknown

COG1576

9.1

7.8

8.6

8.3

9.5

8.2

8.3

9.3

9

8.3

5.2

10.6

X

23.8

21.9

22.7

9.6

11.1

10.1

1to0

sr145

B. subtilis

unknown

COG1576

8.8

7.9

9

8.2

9.2

8.4

7.9

8.3

8.9

8.4

5.9

10.2

23.8

X

26.4

22.4

10.2

11

10.8

1vh0

SAV0024

S. aureus

unknown

COG1576

8.7

7.4

8.5

7.9

9

7.8

7.1

8.5

8.1

7.3

5

8.5

21.9

26.4

X

22.8

10.5

11.2

9.6

1o6d

TM0844

T. maritima

unknown

COG1576

8.2

7.4

9.1

7.9

8

7.8

8.5

9.7

8.7

7.7

5.9

9.7

22.7

22.4

22.8

X

10.3

11.6

11.9

1oy5

TrmD

A. aeolicus

tRNA:m1G37

COG0336

7.2

5.5

7.8

6.6

6.4

6.5

5.9

6.2

6.4

5.8

5.9

7.4

9.6

10.2

10.5

10.3

X

21.1

20.6

1p9p

TrmD

E. coli

tRNA:m1G37

COG0336

8.3

6.4

8.9

7.2

7.3

7.9

6.8

7.3

7.7

7

5.9

7.9

11.1

11

11.2

11.6

21.1

X

29.1

1uaj

TrmD

H. influenzae

tRNA:m1G37

COG0336

7.4

6.3

8.9

6.7

5.9

7.8

6.9

7.1

7.4

6.8

4.9

7.7

10.1

10.8

9.6

11.9

20.6

29.1

X

  1. Structures are described by their PDB IDs. Pairwise structural similarities according to the DALI Z-score (number of standard deviations above the expectation for unrelated structures) are listed, highest values are indicated by black (Z ≥ 15) or grey background (15 > Z ≥ 11). The highest similarity (black shading) correlates very well with membership in different SCOP families within the "α/β knot superfamily".