Predicting mostly disordered proteins by using structure-unknown protein data

BMC Bioinformatics

Table 5 Per-residue sensitivity (SEN) on mostly disordered proteins (average disorder length is 228.54) and sensitivity (SEN) and specificity (SPC) on mostly ordered proteins (average disorder length = 2.47) for the proposed method (SGT) and four per-residue predictors.

	Mostly DISORDERED proteins Ave DR length = 228.54	Mostly ORDERED proteins Ave DR length = 2.47
	SEN	SEN	SPC
SGT	0.834	0.009	0.991
VL3	0.782	0.562	0.880
IUPred (long)	0.666	0.262	0.955
Disopred2	0.645	0.780	0.954
GlobPlot	0.311	0.324	0.838

Specificity for mostly disordered proteins cannot be calculated because sequences selected from DisProt have no information for ordered regions. The 71 predictions by VL3 for mostly ordered sequences were excluded because the VL3 server does not return results for sequences that include ambiguous characters such as 'Z'.

ISSN: 1471-2105