Table 2 Results for five-study simulation data. True integration-driven discovery rate (t IDR) and true integration-driven revision rate (t IRR) for threshold value of posterior probability of differential expression γ = 0.95, and the number of true discovered genes for posterior expected false discovery rate pe FDR = 5%, for the Bayesian standardized expression integration (SEI) and probability integration (PI) models. Results are shown for the three levels of simulated percent differentially expressed genes p _s and three levels of mean inter-study variability ${\tau }_g^2$ for the five-study simulation data.

Five-Study Simulation Data

SEI

PI

SEI

PI

SEI

PI

Low : mean ${\tau }_g^2$ = 0.1 (DE); 0.01(non DE)

t IRR, γ = 0.95

13.7%

34.7%

3.8%

20.6%

0%

11.4%

t IRR, γ = 0.95

4.5%

0%

6.7%

0.6%

15.4%

1.4%

True Genes, pe FDR = 5%

88

106

187

215

496

576

Medium : mean ${\tau }_g^2$ = 0.3 (DE); 0.03 (non DE)

t IDR, γ = 0.95

7.2%

21.3%

2.2%

15.2%

0%

6.7%

t IRR, γ = 0.95

9.4%

0%

10.2%

3.6%

16.8%

3.0%

True Genes, pe FDR = 5%

99

118

212

241

571

642

High : mean ${\tau }_g^2$ = 0.7 (DE); 0.07 (non DE)

t IDR, γ = 0.95

3.8%

13.3%

0%

5.4%

0%

3.4%

t IRR, γ = 0.95

9.8%

0.9%

7.9%

2.8%

10.7%

3.5%

True Genes, pe FDR = 5%

122

135

259

270

654

688