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Table 2 Results for five-study simulation data. True integration-driven discovery rate (t IDR) and true integration-driven revision rate (t IRR) for threshold value of posterior probability of differential expression γ = 0.95, and the number of true discovered genes for posterior expected false discovery rate pe FDR = 5%, for the Bayesian standardized expression integration (SEI) and probability integration (PI) models. Results are shown for the three levels of simulated percent differentially expressed genes p s and three levels of mean inter-study variability τ g 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFepaDdaqhaaWcbaGaem4zaCgabaGaeGOmaidaaaaa@30EE@ for the five-study simulation data.

From: Bayesian meta-analysis models for microarray data: a comparative study

   p s = 5% p s = 10% p s = 25%
Five-Study Simulation Data SEI PI SEI PI SEI PI
Low : mean τ g 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFepaDdaqhaaWcbaGaem4zaCgabaGaeGOmaidaaaaa@30EE@ = 0.1 (DE); 0.01(non DE) t IRR, γ = 0.95 13.7% 34.7% 3.8% 20.6% 0% 11.4%
  t IRR, γ = 0.95 4.5% 0% 6.7% 0.6% 15.4% 1.4%
  True Genes, pe FDR = 5% 88 106 187 215 496 576
Medium : mean τ g 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFepaDdaqhaaWcbaGaem4zaCgabaGaeGOmaidaaaaa@30EE@ = 0.3 (DE); 0.03 (non DE) t IDR, γ = 0.95 7.2% 21.3% 2.2% 15.2% 0% 6.7%
  t IRR, γ = 0.95 9.4% 0% 10.2% 3.6% 16.8% 3.0%
  True Genes, pe FDR = 5% 99 118 212 241 571 642
High : mean τ g 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFepaDdaqhaaWcbaGaem4zaCgabaGaeGOmaidaaaaa@30EE@ = 0.7 (DE); 0.07 (non DE) t IDR, γ = 0.95 3.8% 13.3% 0% 5.4% 0% 3.4%
  t IRR, γ = 0.95 9.8% 0.9% 7.9% 2.8% 10.7% 3.5%
  True Genes, pe FDR = 5% 122 135 259 270 654 688
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BMC Bioinformatics

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