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Figure 4 | BMC Bioinformatics

Figure 4

From: TAMEE: data management and analysis for tissue microarrays

Figure 4

Stained and gridded TMA section. (a) TMA section with about 480 tissue cores from different cancer tissue samples. Cytokeratin has been detected by IHC (brown areas) using a cytokeratin antibody (mouse anti human; DAKO; M3515) and the EnVision detection Kit (DAKO, K4065). Tissue cores are made visible with a Hematoxilin counterstain (light blue). (b) The same section after automatic core localization and shape determination. The outline of a core is displayed in blue. Positions with missing cores (⊗), cores which are too large (more than 160% of the expected area, ) and cores which are too small (less than 40% of the expected area, ) are shown in red. Array positions without a symbol or outline have been deliberately left empty during TMA production. Gridding ambiguities in heavily distorted areas of the array are corrected manually.

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