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Table 1 GO terms mapped to Valle's HDG functional categories

From: Evaluation of high-throughput functional categorization of human disease genes

Valle's functional classifications

GO terms

GO names

Enzyme

GO:0050662

mf:coenzyme binding

Enzyme

GO:0019899

mf:enzyme binding

Enzyme

GO:0050790

bp:regulation of enzyme activity

Enzyme

GO:0003824

mf: catalytic activity

Enzyme

GO:0016591

cc: DNA-directed RNA polymerase II, holoenzyme

Enzyme

GO:0005697

cc: telomerase holoenzyme complex

Enzyme

GO:0017101

cc: aminoacyl-tRNA synthetase multienzyme complex

Modulator protein function

GO:0003754

mf: chaperon activity

Modulator protein function

GO:0003757

mf: chaperon activity

Modulator protein function

GO:0003758

mf: chaperon activity

Modulator protein function

GO:0003760

mf: chaperon activity

Modulator protein function

GO:0003761

mf: chaperon activity

Modulator protein function

GO:0003767

mf: co-chaperon activity

Modulator protein function

GO:0003768

mf: co-chaperon activity

Modulator protein function

GO:0003769

mf: co-chaperon activity

Modulator protein function

GO:0003770

mf: co-chaperon activity

Modulator protein function

GO:0003771

mf: co-chaperon activity

Modulator protein function

GO:0016238

bp: chaperone-related autophagy

Modulator protein function

GO:0007022

bp: chaperone-mediated tubulin folding

Modulator protein function

GO:0007023

bp: post-chaperonin tubulin folding pathway

Modulator protein function

GO:0006462

bp: protein complex assembly, multichaperone pathway

Modulator protein function

GO:0016465

cc:chaperonin ATPase complex

Modulator protein function

GO:0005832

cc: chaperonin-containing T-complex

Receptor

GO:0004872

mf: receptor activity

Receptor

GO:0005102

mf: receptor binding

Receptor

GO:0007166

bp: cell surface receptor linked signal transduction

Receptor

GO:0005057

mf: receptor signaling protein activity

Transcription factor

GO:0003700

mf: transcription factor activity

Transcription factor

GO:0000130

mf: transcription factor activity

Transcription factor

GO:0005667

cc: transcription factor complex

Transcription factor

GO:0042990

bp: regulation of transcription factor-nucleus import

Transcription factor

GO:0042991

bp: transcription factor-nucleus import

Intracellular matrix component

GO:0005622

cc: intracellular

Intracellular matrix component

GO:0046907

bp: intracellular transport

Intracellular matrix component

GO:0008092

mf: cytoskeletal protein binding

Extracellular matrix component

GO:0007160

bp: cell-matrix adhesion

Extracellular matrix component

GO:0009989

bp: cell-matrix recognition

Extracellular matrix component

GO:0005578

cc: extracellular matrix

Extracellular matrix component

GO:0005921

cc: gap junction

Extracellular matrix component

GO:0030055

cc: cell-matrix junction

Extracellular matrix component

GO:0005201

mf: extracellular matrix structural constituent

Extracellular matrix component

GO:0050840

mf: extracellular matrix binding

Transmembrane transporter

GO:0005215

mf: transporter activity

Transmembrane transporter

GO:0000036

mf: acyl carrier activity

Transmembrane transporter

GO:0019793

mf: ISG15 carrier activity

Channel

GO:0015267

mf: channel/pore class transporter activity

Channel

GO:0008282

cc: ATP-sensitive potassium channel complex

Channel

GO:0005891

cc: voltage-gated calcium channel complex

Channel

GO:0016935

cc: glycine-gated chloride channel complex

Channel

GO:0019183

cc: histamine-gated chloride channel complex

Channel

GO:0005892

cc: nicotinic acetylcholine-gated receptor-channel complex

Channel

GO:0008076

cc: voltage-gated potassium channel complex

Channel

GO:0001518

cc: voltage-gated sodium channel complex

Hormone

GO:0042562

mf: hormone binding

Hormone

GO:0005179

mf: hormone activity

Hormone

GO:0005131

mf: growth hormone receptor binding

Hormone

GO:0046879

bp: hormone secretion

Hormone

GO:0009725

bp: response to hormone stimulus

Hormone

GO:0009755

bp: hormone mediated signaling

Hormone

GO:0005831

cc: steroid hormone aporeceptor complex

Hormone

GO:0016914

cc: follicle-stimulating hormone complex

Immunoglobulin

GO:0019865

mf: immunoglobulin binding

Immunoglobulin

GO:0019763

mf: immunoglobulin receptor activity

Immunoglobulin

GO:0048305

bp: IG secretion

Immunoglobulin

GO:0045190

bp: isotype switching

Immunoglobulin

GO:0019814

cc: immunoglobulin complex

Cell signalling

GO:0019955

mf: cytokine binding

Cell signalling

GO:0005125

mf: cytokine activity

Cell signalling

GO:0019221

bp: cytokine and chemokine mediated signaling pathway

Cell signalling

GO:0042089

cytokine biosynthesis

Cell signalling

GO:0019838

mf: growth factor binding

Cell signalling

GO:0008083

mf: growth factor activity