From: Evaluation of high-throughput functional categorization of human disease genes
Valle's Category | Original curation HDG count | True Positives | False Negatives | False Positives | GO-Mapping precision | GO-Mapping recall |
---|---|---|---|---|---|---|
Cell Signalling | 20 | 11 | 9 | 20 | 35% | 55% |
Channel | 32 | 25 | 7 | 15 | 61% | 78% |
Enzyme | 232 | 208 | 24 | 107 | 66% | 90% |
Extracellular matrix component | 54 | 41 | 13 | 25 | 62% | 76% |
Hormone | 14 | 14 | 0 | 1 | 93% | 100% |
Immunoglobulin | 4 | 1 | 3 | 2 | 33% | 25% |
Intracellular matrix component | 50 | 23 | 27 | 207 | 10% | 46% |
Modulator of protein function | 105 | 4 | 101 | 5 | 44% | 4% |
Receptor | 86 | 82 | 4 | 96 | 46% | 95% |
Transcription factor | 79 | 62 | 17 | 10 | 85% | 78% |
Transmembrane Transporter | 35 | 42 | 3 | 102 | 29% | 93% |
Totals & overall accuracy scores | 711 | 513 | 208 | 590* | 47%** | 71%** |