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Table 3 Comparison of GO clustering classification to Valle's categories

From: Evaluation of high-throughput functional categorization of human disease genes

Valle's Category Original curation HDG count True Positives False Negatives False Positives GO-clustering precision GO-clustering recall
Cell Signaling 20 0 20 0 N/A 0%
Channel 32 28 4 7 34% 88%
Enzyme 232 143 89 15 85% 61%
Extracellular matrix component 54 17 37 21 63% 31%
Hormone 14 0 14 0 N/A 0%
Immunoglobulin 4 0 4 0 N/A 0%
Intracellular matrix component 50 42 8 10 43% 84%
Modulator of protein function 105 28 77 231 25% 27%
Receptor 86 58 28 10 73% 67%
Transcription factor 79 68 11 4 73% 86%
Transmembrane Transporter 35 15 20 42 32% 43%
Totals & overall accuracy scores 711 399 312 340 62%** 56%**
  1. ** Overall accuracy scores are calculated from the overall True positive, false positive and false negative scores (they are not an average of the categorical accuracy scores)
  2. N/A: not applicable because precision cannot be calculated for categories with 0 true positive results and 0 false positives (zero divided by zero).