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Figure 5 | BMC Bioinformatics

Figure 5

From: Preliminary nanopore cheminformatics analysis of aptamer-target binding strength

Figure 5

Level duration feature extraction for the 6 T pseudo-aptamer. First feature extraction for the pseudo-aptamer bound to its complementary 5 base pair sequence. The y-axis is the transition probability, while the x-axis is the HMM Profile: 150 feature vectors components are obtained from the 50-state HMM-EM/Viterbi implementation in [4] are: the 50 dwell percentage in the different blockade levels (from the Viterbi trace-back states), the 50 variances of the emission probability distributions associated with the different states, and the 50 merged transition probabilities from the primary and secondary blockade occupation levels (fits to two-state dominant modulatory blockade signals).

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