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Table 2 List of predicted targets that are known genes affected in Colon Cancer

From: Computational analysis of biological functions and pathways collectively targeted by co-expressed microRNAs in cancer

Name Description Location Type Drugs
AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) Cytoplasm kinase enzastaurin
APC adenomatosis polyposis coli Nucleus enzyme  
BAX BCL2-associated X protein Cytoplasm other  
BCL2L11 BCL2-like 11 (apoptosis facilitator) Cytoplasm other  
BIRC5 baculoviral IAP repeat-containing 5 (survivin) Cytoplasm other  
BRCA1 breast cancer 1, early onset Nucleus transcription regulator  
CCND1 cyclin D1 Nucleus other  
DIABLO diablo homolog (Drosophila) Cytoplasm other  
EP300 E1A binding protein p300 Nucleus transcription regulator  
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Plasma Membrane kinase  
FASLG Fas ligand (TNF superfamily, member 6) Extracellular Space cytokine  
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) Plasma Membrane kinase sunitinib, axitinib
FST follistatin Extracellular Space other  
GSK3A glycogen synthase kinase 3 alpha Nucleus kinase  
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) Plasma Membrane transmembrane receptor  
MAP2K1 mitogen-activated protein kinase kinase 1 Cytoplasm kinase PD 0325901
MAPK9 mitogen-activated protein kinase 9 Cytoplasm kinase  
MAPK14 mitogen-activated protein kinase 14 Cytoplasm kinase SCIO-469
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive Nucleus transcription regulator  
NUAK1 NUAK family, SNF1-like kinase, 1 Unknown kinase  
PARP1 poly (ADP-ribose) polymerase family, member 1 Nucleus enzyme INO-1001
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) Nucleus other  
PLK1 polo-like kinase 1 (Drosophila) Nucleus kinase  
PPP2R1B protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform Unknown phosphatase  
PRKCA protein kinase C, alpha Cytoplasm kinase safingol
PRKG1 protein kinase, cGMP-dependent, type I Cytoplasm kinase  
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Cytoplasm kinase dasatinib
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) Plasma Membrane kinase  
YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 Cytoplasm kinase dasatinib