Table 2 List of predicted targets that are known genes affected in Colon Cancer
Name | Description | Location | Type | Drugs |
|---|---|---|---|---|
AKT3 | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | Cytoplasm | kinase | enzastaurin |
APC | adenomatosis polyposis coli | Nucleus | enzyme | Â |
BAX | BCL2-associated X protein | Cytoplasm | other | Â |
BCL2L11 | BCL2-like 11 (apoptosis facilitator) | Cytoplasm | other | Â |
BIRC5 | baculoviral IAP repeat-containing 5 (survivin) | Cytoplasm | other | Â |
BRCA1 | breast cancer 1, early onset | Nucleus | transcription regulator | Â |
CCND1 | cyclin D1 | Nucleus | other | Â |
DIABLO | diablo homolog (Drosophila) | Cytoplasm | other | Â |
EP300 | E1A binding protein p300 | Nucleus | transcription regulator | Â |
ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | Plasma Membrane | kinase | Â |
FASLG | Fas ligand (TNF superfamily, member 6) | Extracellular Space | cytokine | Â |
FLT1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | Plasma Membrane | kinase | sunitinib, axitinib |
FST | follistatin | Extracellular Space | other | Â |
GSK3A | glycogen synthase kinase 3 alpha | Nucleus | kinase | Â |
ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Plasma Membrane | transmembrane receptor | Â |
MAP2K1 | mitogen-activated protein kinase kinase 1 | Cytoplasm | kinase | PD 0325901 |
MAPK9 | mitogen-activated protein kinase 9 | Cytoplasm | kinase | Â |
MAPK14 | mitogen-activated protein kinase 14 | Cytoplasm | kinase | SCIO-469 |
NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | Nucleus | transcription regulator | Â |
NUAK1 | NUAK family, SNF1-like kinase, 1 | Unknown | kinase | Â |
PARP1 | poly (ADP-ribose) polymerase family, member 1 | Nucleus | enzyme | INO-1001 |
PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | Nucleus | other | Â |
PLK1 | polo-like kinase 1 (Drosophila) | Nucleus | kinase | Â |
PPP2R1B | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform | Unknown | phosphatase | Â |
PRKCA | protein kinase C, alpha | Cytoplasm | kinase | safingol |
PRKG1 | protein kinase, cGMP-dependent, type I | Cytoplasm | kinase | Â |
SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | Cytoplasm | kinase | dasatinib |
TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | Plasma Membrane | kinase | Â |
YES1 | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | Cytoplasm | kinase | dasatinib |