Table 3 List of predicted targets that are known genes affected in Pancreatic Cancer
Name | Description | Location | Type | Drugs |
|---|---|---|---|---|
AKT1 | v-akt murine thymoma viral oncogene homolog 1 | Cytoplasm | kinase | enzastaurin |
BCL2 | B-cell CLL/lymphoma 2 | Cytoplasm | other | oblimersen |
CCKBR | cholecystokinin B receptor | Plasma Membrane | G-protein coupled receptor | CR 2945 |
CDK6 | cyclin-dependent kinase 6 | Nucleus | kinase | flavopiridol |
CTSB | cathepsin B | Cytoplasm | peptidase | Â |
CTSL2 | cathepsin L2 | Cytoplasm | peptidase | Â |
E2F1 | E2F transcription factor 1 | Nucleus | transcription regulator | Â |
FAS | Fas (TNF receptor superfamily, member 6) | Plasma Membrane | transmembrane receptor | Â |
HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | Extracellular Space | growth factor | Â |
HMGA1 | high mobility group AT-hook 1 | Nucleus | transcription regulator | Â |
IL6 | interleukin 6 (interferon, beta 2) | Extracellular Space | cytokine | Â |
KRAS | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | Cytoplasm | enzyme | Â |
PLAU | plasminogen activator, urokinase | Extracellular Space | peptidase | Â |
RHOB | ras homolog gene family, member B | Cytoplasm | enzyme | Â |
THOC1 | THO complex 1 | Nucleus | other | Â |
TOP1 | topoisomerase (DNA) I | Nucleus | enzyme | elsamitrucin, T 0128, CT-2106, BN 80927, tafluposide, TAS-103, irinotecan, topotecan, 9-amino-20-camptothecin, rubitecan, gimatecan, karenitecin |
TP53 | tumor protein p53 (Li-Fraumeni syndrome) | Nucleus | transcription regulator | Â |