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Table 3 List of predicted targets that are known genes affected in Pancreatic Cancer

From: Computational analysis of biological functions and pathways collectively targeted by co-expressed microRNAs in cancer

Name Description Location Type Drugs
AKT1 v-akt murine thymoma viral oncogene homolog 1 Cytoplasm kinase enzastaurin
BCL2 B-cell CLL/lymphoma 2 Cytoplasm other oblimersen
CCKBR cholecystokinin B receptor Plasma Membrane G-protein coupled receptor CR 2945
CDK6 cyclin-dependent kinase 6 Nucleus kinase flavopiridol
CTSB cathepsin B Cytoplasm peptidase  
CTSL2 cathepsin L2 Cytoplasm peptidase  
E2F1 E2F transcription factor 1 Nucleus transcription regulator  
FAS Fas (TNF receptor superfamily, member 6) Plasma Membrane transmembrane receptor  
HGF hepatocyte growth factor (hepapoietin A; scatter factor) Extracellular Space growth factor  
HMGA1 high mobility group AT-hook 1 Nucleus transcription regulator  
IL6 interleukin 6 (interferon, beta 2) Extracellular Space cytokine  
KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog Cytoplasm enzyme  
PLAU plasminogen activator, urokinase Extracellular Space peptidase  
RHOB ras homolog gene family, member B Cytoplasm enzyme  
THOC1 THO complex 1 Nucleus other  
TOP1 topoisomerase (DNA) I Nucleus enzyme elsamitrucin, T 0128, CT-2106, BN 80927, tafluposide, TAS-103, irinotecan, topotecan, 9-amino-20-camptothecin, rubitecan, gimatecan, karenitecin
TP53 tumor protein p53 (Li-Fraumeni syndrome) Nucleus transcription regulator