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Table 1 For all row entries the average dwell time of both the upper and lower signal levels increases proportionately with bin-count.

From: A novel, fast, HMM-with-Duration implementation – for application with a new, pattern recognition informed, nanopore detector

Bin # 2-state Geometric HMM 2n-state Explicit HMMwD 2-state Implicit HMMwD
10 743876 832514 756765
100 951916 960272 953151
1000 995388 995408 995381
  1. Thus the resolution of the duration distribution for both the signal-generating and the signal-decoding HMM's are identical for all row entries. Upper and lower mean durations are .2 and .6 times that of the bin count, respectively. Upper and lower mean emissions are 50.0 and 45.0, respectively, whereas the emission variance for both upper and lower is 20.0. In other tests (see Fig. 7 and figures in the Additional Files), the decoding duration distribution is an increasingly refined step function approximation of the generating duration distribution. For the data shown in this table, both upper and lower dwell-time distributions are 2-component beta-mixtures that are monotonically decreasing. The numbers shown represent the accuracy of Viterbi decoding out of an input signal 1 M samples in length.