Cluster | Gene names | Network's top functions | Canonical pathways |
---|---|---|---|
#1 0.5 hours post infection, up | ACTR2 , C12orf23 , CGI-38 , CPM , DGKE , FLJ22471 , GALNT10 , H2AFY2 , LOC197350 , LRRC51 , MAD1L1 , PHOSPHO2 , PIP5K1A , PPIB , PTCRA , PTPRN2 , TEKT1 , TMTC4, *,* No significant networks assembled | Cell Cycle, Cell Death, Cell-to Cell Signaling and Interaction, Immune and Lymphatic System Development and Function | O-glycan biosynthesis, Phospholipid Degradation, Inositol Phosphate Metabolism, Glycerophospholipid Metabolism, Glycerolipid Metabolism |
#2 1 hours post infection, up | ACP1, AKT2, BBC3, CD19, CHGA, CKM, CSDA, CTSD, DDX5, EEF2, EGR1, GTF2I, HAS2, HOXA5, IER3, IGF1, MYC, PGK1, PRDM1, PRNP, ROCK2, RPS6, SRC, TLN1 | Cellular Growth and Proliferation, Cellular Development, Cell Death, Cell-to-Cell Signaling and Interaction, Tissue Development | Neuregulin Signaling, Ephrin Receptor Signaling, Wnt/β-catenin Signaling, PDGF Signaling, Integrin Signaling, ERK/MAPK Signaling, B Cell Receptor Signaling |
#3 1.5 hours post infection, up | ADK, APBB1, BTN3A3, CHST2, CLIC1, EB-1, EI24, ENAH, F2, FARS2 , FAS, FOS, GNPAT , GRB7 , IL2RA , KAL1 , NDRG1, PDRG1, PRKAB2, SMARCB1, TCF3, TNF, TP53, TP73L, TWIST2, VASP | Cellular Movement, Organismal Survival, Connective Tissue Development and Function, Cell Cycle | Apoptosis signaling, Wnt/β-catenin Signaling, PPAR Signaling, p38 MAPK Signaling, Integrin Signaling, IL-6,-2,-10 Signaling, Death Receptor Signaling |
#4 1.5 hours post infection, down | AATF, AKT3, ARNTL , CENPF , COL18A1, CREG1, CRI1, CTDSPL, E2F1, E4F1, EP300, FEZ1, HIF1AN, KCNJ1, KLF5, POLR2F , PPT2, PRKCZ, RB1, RBBP9, SLC29A2, SRC, STAT5B, TBP, UMPS, ZBTB16 | Cellular Growth and Proliferation, Gene Expression, Cellular Development, Cell Death, Cell Cycle | Estrogen Receptor Signaling, NF-κB Signaling, Neuregulin Signaling, Xenobiotic Metabolism Signaling, Wnt/β-catenin Signaling, Pyrimidine Metabolism, PTEN Signaling, PPAR Signaling, Jak/Stat Signaling, Integrin Signaling, IL-2 Signaling |
#5 4 hours post infection, up | ABCA1, ALPP, C7, CCNG2, ENPP1, ERBB3, F3, FLOT1, FPRL1, G6PD, IL1B, KLF10, KRT17, MEFV, NAB2, PCSK1, PTX3 , RRS1, S100A6, SERPINH1, SLC20A1, TGFB1, THBD, TNFAIP2 | Cellular Growth and Proliferation, Hematological Disease, Cellular Movement, Organismal Development, Cell-to Cell Signaling and Interaction | Complement and Coagulation Cascades, p38 MAPK Signaling, Xenobiotic Metabolism Signaling, Wnt/β-catenin Signaling, TGF-β Signaling, Starch and Sucrose Metabolism, Riboflavin Metabolism, Purine Metabolism, PPAR Signaling |
#6 4 hours post infection, down | ARL3, CASP14, FCER1A, FOXC1, G0S2, HOXA9, KIF3C, KPNA3,MLL, NDUFS4, NDUFV2 , PEX14 , RANBP9 , RBL1, RFP, SERPINB10, SERPINC1 , SERPINE1 , SLC34A1, SLC7A1, SMYD3, TFE3, TGFB1, TNF, WWOX | Cellular Development, Cellular Growth and Proliferation, Hematological System Development and Function, Immune and Lymphatic System Development and Function | Ubiquinone Biosynthesis, TGF-β Signaling, p38 MAPK Signaling, Oxidative Phosphorylation, Complement and Coagulation Cascades, Cell Cycle G1/S Checkpoint Regulation, Xenobiotic Metabolism Signaling, Wnt/β-catenin Signaling, PPAR Signaling |
#7 6 hours post infection, up | P29 , CIRH1A , KIF1B , GPR51 , GPS1 , BMPR2 , THBD*,* No significant networks assembled | Cell Morphology, Cardiovascular Disease, Genetic Disorder, Nervous System Development and Function, Organ Morphology | Pentose Phosphate Pathway, EGF Signaling, IL-2 Signaling, Jak/Stat Signaling, Fructose and Mannose Metabolism, Galactose Metabolism |
#8 8 hours post infection, up | CCR2, CDC45L, CRABP2, CSF3R, DIO1, E2F1, EXOSC9, GBP2, IL4, IL6, INDO, KCNJ5, KIAA0101, MAZ, NR1H4 , NUP62 , PFKL, POLD1, PROS1, RAF1, RXRA, SP1, THRA | Gene Expression, Cell Death, Hepatic System Disease, Cellular Function and Maintenance, Cellular Growth and Proliferation | Xenobiotic Metabolism Signaling, IL-10,-6 Signaling, PPAR Signaling, VEGF Signaling, Tryptophan Metabolism, TGF-β Signaling, T Cell Receptor Signaling, Pyrimidine Metabolism |
#9 8 hours post infection, down | ALAD, CPT2, CPT1A, CRYAB, EEF2, GAS1, GCK, GSK3A, INSR, MNT, MXI1, MYC, NDRG1, ONECUT1, PDE3B, PKLR, PTPN2, PTPRG, RPL5, SOCS6, SORBS1, TAT, TUB | Metabolic Disease, Cell Cycle, Connective Tissue Development and Function, Cellular Growth and Proliferation, Carbohydrate Metabolism | Insulin Receptor Signaling, Wnt/β-catenin Signaling, Purine Metabolism, Glycolysis/Glyconeogenesis, Fatty Acid Metabolism, Tyrosine Metabolism |
#10 10 hours post infection, down | ACTN4, ADAM10, AIM1, ARID1B, COL2A1, CTNNB1, CTNNBIP1, CTSH, FZD8, IHH, LFNG, MMP2, NOTCH1, NRP2, PIN1, SFTPB, SLC26A2, SMARCA4, SOCS1, STXBP3 | Organismal Development, Embryonic Development, Tissue Development, Cellular Development | Wnt/β-catenin Signaling, NOTCH Signaling, VEGF Signaling, Purine Metabolism, PI3K/AKT Signaling, Jak/Stat Signaling, Interferon Signaling, Integrin Signaling, IL-6,-4,-2 Signaling |