Figure 4

Antibody Signal Classes and Ab-Antigen Signal Classes. A-D: various IgG region captures and their associated toggle signals (1 second traces). E-F: various IgG+Antigen region captures and their associated toggle signals (1 second traces). Each blockade signal was identified visually and represents a commonly observed signal class. Note the changes in dwell times for the upper and lower current levels in each signal class. We find a higher current level bias in the level occupancy as a result of binding with the antigen molecule.