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Figure 5 | BMC Bioinformatics

Figure 5

From: Nanopore-based kinetics analysis of individual antibody-channel and antibody-antigen interactions

Figure 5

Antibody-Antigen Binding Event. An antibody molecule has been captured by the Alpha-hemolysin channel producing a clear and continuous toggle signal. Antigen is introduced to the 70 ul cis well of the nanopore chamber in frame (A). Subsequent data files containing toggle signals of three minute intervals are recorded and displayed as B, C, and D (only the first second of each 3 minute phase is shown). Changes to the toggle signal are detected in frames C and D indicating the binding event between the antibody and antigen has taken place.

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