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Figure 6 | BMC Bioinformatics

Figure 6

From: Nanopore-based kinetics analysis of individual antibody-channel and antibody-antigen interactions

Figure 6

Multivalent antigen binding. Top Panel: First Antibody Antigen Binding – 1st 50 feature components extracted from the HMM in Fig 2. Bottom Panel: Shifts in the values of these 1st 50 HMM feature components indicate a possible second Antibody Antigen Binding (same molecular capture). The first 50 components of the 150 feature vectors obtained from the 50-state HMM-EM/Viterbi implementation are the dwell percentages in the different blockade levels from the Viterbi trace-back states (approximately the Histogram in that range).

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