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Table 1 Genes involved in drug metabolism altered by comfrey and riddelliine treatments in liver

From: Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver

Gene symbol Gene description Locus link ID Fold changea
    Comfrey Riddelliine
Phase I metabolism    
Ces2 carboxylesterase 2 (intestine, liver) 171118 10.4 2.4
Cyp2c cytochrome P450, subfamily IIC 29277 -24.3 -270.3
Cyp2c40 cytochrome P450, family 2, subfamily c 25011 8.7 42.3
Cyp2e1 cytochrome P450, family 2, subfamily e 25086 2.2 2.1
Fmo5 flavin containing monooxygenase 5 246248 4.1 4.2
Phase II metabolism    
Gsta3 glutathione S-transferase, alpha 3 14859 22.5 13.4
Inmt indolethylamine N-methyltransferase 21743 -29.3 -11.7
Nqo1 NAD(P)H dehydrogenase, quinone 1 24314 5.0 2.6
Sult1c1 sulfotransferase family, cytosolic,1C, member1 65185 -2.7 -3.2
Phase III metabolism    
Abcb1 ATP-binding cassette, sub-family B 24646 97.0 11.3
Abcb9 ATP-binding cassette, sub-family B, member 9 63886 -5.0 -2.7
Abcc3 ATP-binding cassette, sub-family C, member 3 140668 25.1 10.8
Abcc8 ATP-binding cassette, sub-family C, member 8 25559 -9.7 -2.6
Atp13a5 ATPase type 13A5 268878 -3.6 -4.1
Slc13a5 solute carrier family 13, member 5 266998 -2.9 -2.4
Slc16a4 solute carrier family 16, member 4 229699 -2.8 -4.9
Slc22a6 solute carrier family 22, member 6 29509 -3.7 -2.4
Slc22a8 solute carrier family 22, member 8 83500 -12.2 -833.3
Slc25a21 solute carrier family 25, member 21 171151 4.4 2.7
Slc25a30 solute carrier family 25, member 30 67554 -4.5 -2.7
  1. aThe symbol of minus (-) means down-regulation, and the P-value for all genes is less than 0.01.