Table 1 Genes involved in drug metabolism altered by comfrey and riddelliine treatments in liver
From: Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver
Gene symbol | Gene description | Locus link ID | Fold changea | |
|---|---|---|---|---|
| Â | Â | Â | Comfrey | Riddelliine |
Phase I metabolism | Â | Â | Â | |
Ces2 | carboxylesterase 2 (intestine, liver) | 171118 | 10.4 | 2.4 |
Cyp2c | cytochrome P450, subfamily IIC | 29277 | -24.3 | -270.3 |
Cyp2c40 | cytochrome P450, family 2, subfamily c | 25011 | 8.7 | 42.3 |
Cyp2e1 | cytochrome P450, family 2, subfamily e | 25086 | 2.2 | 2.1 |
Fmo5 | flavin containing monooxygenase 5 | 246248 | 4.1 | 4.2 |
Phase II metabolism | Â | Â | Â | |
Gsta3 | glutathione S-transferase, alpha 3 | 14859 | 22.5 | 13.4 |
Inmt | indolethylamine N-methyltransferase | 21743 | -29.3 | -11.7 |
Nqo1 | NAD(P)H dehydrogenase, quinone 1 | 24314 | 5.0 | 2.6 |
Sult1c1 | sulfotransferase family, cytosolic,1C, member1 | 65185 | -2.7 | -3.2 |
Phase III metabolism | Â | Â | Â | |
Abcb1 | ATP-binding cassette, sub-family B | 24646 | 97.0 | 11.3 |
Abcb9 | ATP-binding cassette, sub-family B, member 9 | 63886 | -5.0 | -2.7 |
Abcc3 | ATP-binding cassette, sub-family C, member 3 | 140668 | 25.1 | 10.8 |
Abcc8 | ATP-binding cassette, sub-family C, member 8 | 25559 | -9.7 | -2.6 |
Atp13a5 | ATPase type 13A5 | 268878 | -3.6 | -4.1 |
Slc13a5 | solute carrier family 13, member 5 | 266998 | -2.9 | -2.4 |
Slc16a4 | solute carrier family 16, member 4 | 229699 | -2.8 | -4.9 |
Slc22a6 | solute carrier family 22, member 6 | 29509 | -3.7 | -2.4 |
Slc22a8 | solute carrier family 22, member 8 | 83500 | -12.2 | -833.3 |
Slc25a21 | solute carrier family 25, member 21 | 171151 | 4.4 | 2.7 |
Slc25a30 | solute carrier family 25, member 30 | 67554 | -4.5 | -2.7 |