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Table 2 NMR detected metabolic biomarkers of age. Age-related metabolite normalized concentrations reported as μM detected by NMR in urine.

From: Metabonomics evaluations of age-related changes in the urinary compositions of male Sprague Dawley rats and effects of data normalization methods on statistical and quantitative analysis

Postulated identity 25 Days (μM) 40 Days (μM) 80 Days (μM)
2-Oxoglutarate 48.3 ± 16.6 85.3 ± 14.3†
p = 2.0E-07 vs. 25
62.5 ± 24.8‡
p = 4.0E-03 vs. 40
Acetate 24.1 ± 26.7 9.1 ± 5.4†
p = 4.3E-02 vs. 25
16.9 ± 20.6
Alanine 5.0 ± 1.9 2.7 ± 0.6†
p = 1.9E-04 vs. 25
3.0 ± 2.1†
p = 7.6E-03 vs. 25
Betaine 8.2 ± 3.5 9.2 ± 5.6 2.5 ± 1.1†‡
p = 9.1E-06 vs. 25
p = 2.4E-04 vs. 40
Citrate 94.6 ± 48.8 164.2 ± 33.7†
p = 7.0E-05 vs. 25
104.6 ± 36.5‡
p = 4.1E-05 vs. 40
Creatine 11.7 ± 2.5 4.2 ± 2.3†
p = 1.0E-09 vs. 25
7.1 ± 12.3
Creatinine 18.4 ± 3.5 26.3 ± 4.0†
p = 1.6E-06 vs. 25
50.9 ± 13.5†‡
p = 4.5E-08 vs. 25
p = 1.6E-06 vs. 40
Formate 11.7 ± 7.4 7.3 ± 1.7†
p = 3.2E-02 vs. 25
5.7 ± 2.3†‡
p = 6.4E-03 vs. 25
p = 4.0E-02 vs. 40
Fumarate 1.9 ± 0.9 1.6 ± 0.3 1.0 ± 0.4†‡
p = 1.0E-03 vs. 25
p = 1.6E-05 vs. 40
Glutamate 2.5 ± 1.2 1.7 ± 0.3†
p = 1.0E-02 vs. 25
1.2 ± 0.3†‡
p = 2.9E-04 vs. 25
p = 5.7E-05 vs. 40
Glutamine 3.7 ± 1.2 2.4 ± 0.5†
p = 5.4E-04 vs. 25
2.6 ± 0.8†
p = 2.8E-03 vs. 25
Hippurate 25.4 ± 13.9 40.6 ± 6.4†
p = 6.9E-04 vs. 25
37.2 ± 15.9†
p = 3.3E-02 vs. 25
Oxalacetate 36.1 ± 15.5 20.0 ± 5.7†
p = 9.4E-04 vs. 25
13.5 ± 5.7†‡
p = 2.7E-05 vs.25
p = 2.9E-03 vs. 40
Pyruvate 2.2 ± 2.1 1.4 ± 0.5 1.1 ± 0.7
Succinate 8.6 ± 2.1 6.9 ± 1.2†
p = 6.5E-03 vs. 25
8.3 ± 2.9
Taurine 2.7 ± 2.1 1.6 ± 0.7 19.5 ± 19.3†‡
p = 3.4E-03 vs. 25
p = 2.1E-03 vs. 40
trans-Aconitate 26.2 ± 4.9 30.2 ± 4.4†
p = 2.1E-02 vs. 25
22.3 ± 6.1‡
p = 2.8E-04 vs. 25