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Figure 17 | BMC Bioinformatics

Figure 17

From: The α-Hemolysin nanopore transduction detector – single-molecule binding studies and immunological screening of antibodies and aptamers

Figure 17

DNA hairpin bound to antibody via an EDC-linker. Approximately shown to scale. Arrow points to the Internal Amino Thymine Modification with Primary Amine on a six carbon spacer arm. Primary amine can be crosslinked using 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) to the peptide carboxyl terminus of the antibody heavy chain. This crosslinkage results in a covalent bond between the primary amine and the carboxyl.

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