Table 1 The table shows a comparison of the known M-CSF dependent macrophage differentiation pathways and the results of our gene expression mode analysis as described in the text. MM = meta-mode, PW = pathway, II & D = Innate immunity and defense, Cell C. = Cell communication, FAM = Fatty acid metabolism, DNA-P = DNA-protection.

Total

MM

PW

Differentiation

PI3Akt

JAK/STAT

MEK/ERK

MAPK

3.2

67

32

12

12.2

53

40

18

II & D

13.2

60

26

-

Cell C.

6.2

62

29

29

TP53 DNA protection

JUN/FOS

4.1

43

22

3

10.1

48

22

10

FAM

11.2

47

23

12

TP53 (DNA-P.)

14.1

64

34

12

NF-κ B

TP53 (DNA-protection)

5.2

43

25

8

11.1

55

22

13

12.1

64

23

12

Apoptosis

TP53 (DNA-protection)

2.1

55

17

5

3.1

57

18

6

6.1

74

28

12

8.1

37

10

7

9.2

43

19

8

13.1

38

23

7

Survival

Prenylated-proteins Rho kinase

BAX

3.1

57

18

10

8.1

37

10

11

13.1

38

23

16

CALR

4.2

58

24

6

FAS

9.2

43

19

11