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Figure 3 | BMC Bioinformatics

Figure 3

From: SPIKE – a database, visualization and analysis tool of cellular signaling pathways

Figure 3

Regulation as target of another regulation. (A). The ability to define a regulation as a target of another regulation is helpful in cases where the effect of regulator A on target B is transmitted to some but not all targets of B. In this schematic example, A specifically inhibits the B-mediated activation of C. (B). A schematic representation of p53 activation by CHK2 [31]. (C). A more specific representation: here, the information that the activation of p53 is achieved by CHK2 interfering with the inhibition of p53 by MDM2 is explicitly represented. This interference is achieved by CHK2 phosphorylation of p53 [31], and therefore the 'physical target' attribute of this regulation is p53.

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