Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in drosophila melanogaster

Table 1 Top predictable GO biological processes identified using SVM and tenfold validation with the data of individual tissues or the combined data

Term	Name	Model^a	TN	FP	FN	TP	Adj.P^c
GO:0006118	electron transport	CM	1128	100	56	26	1.35-E06
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome	CM	1263	41	0	6	1.66-E06
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	CM	1227	59	6	18	1.12-E11
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	CM	1259	42	5	4	6.78-E03
GO:0006629	lipid metabolic process	Brain	1004	245	41	20	2.01-E01
GO:0006637	acyl-CoA metabolic process	Gut	1044	259	2	5	1.05-E01
GO:0006858	extracellular transport	Fat	1105	169	21	15	2.43-E03
GO:0008643	carbohydrate transport	Fat	1167	126	9	8	5.33-E03
GO:0006869	lipid transport	Gut	1051	241	7	11	5.07-E03
GO:0005975	carbohydrate metabolic process	Fat	1140	115	38	17	6.40-E04
GO:0006099	tricarboxylic acid cycle	Testis	1218	75	7	10	6.34-E04
GO:0006511	ubiquitin -deoendent protein catabolic process	Testis	1075	219	7	9	1.69-E02
GO:0016579	protein deubiquitination	Testis	1043	258	2	7	1.36-E02
GO:0006030	chitin metabolic process	CM	1187	108	6	9	1.22-E04
GO:0051189	prosthetic group metabolic process	MT	1136	157	10	7	6.73-E02
GO:0007067	mitosis	MT	1082	213	8	7	1.31-E01
GO:0006350	transcription	Fat	1203	94	9	4	2.01-E02
GO:0007031	peroxisome organization and biogenesis	Gut	1146	156	3	5	2.53-E02
GO:0006625	protein targeting to perosisome	Gut	1129	174	2	5	2.42-E02
GO:0007498	Mesoderm development	MT	1077	223	5	5	2.03-E01
GO:0015986	ATP synthesis coupled proton transport	DTM	1224	73	9	4	1.11-E01

^a The tissues (or organs) generating the data used for model training and validation where MT and DTM represent malpighian tubule, and dorsal thoracic muscle, respectively, and CM represents combined data. ^b SN and SP represent sensitivity and specificity, respectively. ^c FDR-adjusted p-value.

ISSN: 1471-2105