TY - JOUR AU - Janssen, Stefan AU - Reeder, Jens AU - Giegerich, Robert PY - 2008 DA - 2008/02/29 TI - Shape based indexing for faster search of RNA family databases JO - BMC Bioinformatics SP - 131 VL - 9 IS - 1 AB - Most non-coding RNA families exert their function by means of a conserved, common secondary structure. The Rfam data base contains more than five hundred structurally annotated RNA families. Unfortunately, searching for new family members using covariance models (CMs) is very time consuming. Filtering approaches that use the sequence conservation to reduce the number of CM searches, are fast, but it is unknown to which sacrifice. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-9-131 DO - 10.1186/1471-2105-9-131 ID - Janssen2008 ER -