A software application for comparing large numbers of high resolution MALDI-FTICR MS spectra demonstrated by searching candidate biomarkers for glioma blood vessel formation

Table 2 A fragment of mass and intensity peaks lists of 2 samples, illustrating the "missing data" problem.

A) Missing data problem. It appears that the signal intensity from of a peptide mass of 1193.6166 Da in sample 2 is not matched with an intensity of the peptide mass from another sample 1 and vice versa the intensity of peptide mass of 1197.1376 Da of sample 2 is not observed in sample 1.
B) More reliable comparison including background noise signal by recording all the peaks with intensities between the baseline and the S/N threshold in a "noise peaks" file.
A.U. = arbitrary units

ISSN: 1471-2105