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Figure 2 | BMC Bioinformatics

Figure 2

From: Clustering of cognate proteins among distinct proteomes derived from multiple links to a single seed sequence

Figure 2

Distance tree showing very similar inparalogs A2 and A3. The best hit of sequence A3 (Seed), within organism B, is B1. However, when B1 is reciprocally aligned against sequences from organism A, A2 is the best hit, not A3, since A2 and A3 are very similar inparalogs. B1 is considered to form a BBH with A3 (Seed) if A3 appears at the 2nd position in the reciprocal alignment and A2 has a BBH relationship with A3. Another 'hidden inparalogy' case occurs with inparalog searches beginning with A1 being A2 and A3 inparalog candidates. A2 is considered to form a BBH with A1 (Seed) if A1 appears at the 2nd position in the reciprocal alignment and A2 has a BBH relationship with A3.

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BMC Bioinformatics

ISSN: 1471-2105

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