Table 6 Top 10 most frequently observed SNP-pairs in the 100 highest scoring triplet SNP combinations associated with colon cancera.
From: Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions
SNP Pair | Frequency of SNP Pair Observed in Each Scoring Function and Overall | ||||||||
|---|---|---|---|---|---|---|---|---|---|
SNP-1 | SNP-2 | %Correct | Sensitivity +Specificity | PPV+NPV | Risk Ratio | Odds Ratio | Gini Index | Probability Difference | Total (Overall) |
IL1B_01 | IL1B_03 | 9 | 7 | 0 | 0 | 1 | 71 | 3 | 91 |
CASP8_03 | GSTT1_02 | 20 | 21 | 4 | 0 | 4 | 0 | 3 | 52 |
CHEK1_02 | TGFB1_02 | 0 | 0 | 14 | 17 | 14 | 0 | 0 | 45 |
MTRR_01 | SOD2_01 | 9 | 9 | 3 | 0 | 3 | 4 | 11 | 39 |
CDC25A_02 | PTGS2_11 | 0 | 0 | 10 | 12 | 10 | 0 | 0 | 32 |
CHEK1_02 | CDC25A_02 | 0 | 0 | 10 | 11 | 10 | 0 | 0 | 31 |
CHEK1_02 | PTGS2_11 | 0 | 0 | 8 | 8 | 8 | 0 | 0 | 24 |
CHEK1_02 | ALOX5_07 | 0 | 0 | 7 | 7 | 7 | 0 | 0 | 21 |
IL4_01 | XRCC1_1 | 4 | 7 | 3 | 0 | 3 | 1 | 2 | 20 |
MTRR_01 | DIO1_04 | 3 | 3 | 1 | 0 | 1 | 3 | 9 | 20 |