Figure 6

Location of 1QGN residues with highest conn(k) -values. The cystathionine γ synthase consists of two domains. Residues 48 – 307 constitute the PLP binding domain 1QGN A01 (plotted in blue). Residues 308 – 445 constitute domain 1QGN A02 (plotted in yellow), which binds the substrate cysteine. Residues possessing conn(k)-values ≥ 4 were plotted in space filling mode. The conn(k)-values were: conn(388) = 10, conn(268) = 8, conn(305) = conn(386) = conn(391) = conn(393) = 5, conn(308) = 4.